Why “central dogma”?

In a 1958 paper, F. Crick proposed that the information flow from DNA to RNA to Protein is unidirectional.

But “the word dogma caused almost more trouble than it was worth”.

Text from: F. Crick, What Mad Pursuit: A Personal View of Scientific Discovery, 1988, Ch. 10.

Crick F. What Mad Pursuit: A Personal View of Scientific Discovery, 1988, Ch. 10.

Crick FHC. On protein synthesis. Symposia of the Society for Experimental Biology, no. XII, 1958, pp. 138-163 (reprint). Wellcome Collection.

Script: F. Crick, RA (ed.)

Narration: J. Collette

Animation: A. Mehar